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Article Dans Une Revue Cell Metabolism Année : 2015

Transplanted Bone Marrow-Derived Cells Contribute to Human Adipogenesis

Résumé

Because human white adipocytes display a high turnover throughout adulthood, a continuous supply of precursor cells is required to maintain adipogenesis. Bone marrow (BM)-derived progenitor cells may contribute to mammalian adipogenesis; however, results in animal models are conflicting. Here we demonstrate in 65 subjects who underwent allogeneic BM or peripheral blood stem cell (PBSC) transplantation that, over the entire lifespan, BM/PBSC-derived progenitor cells contribute ∼10% to the subcutaneous adipocyte population. While this is independent of gender, age, and different transplantation-related parameters, body fat mass exerts a strong influence, with up to 2.5-fold increased donor cell contribution in obese individuals. Exome and whole-genome sequencing of single adipocytes suggests that BM/PBSC-derived progenitors contribute to adipose tissue via both differentiation and cell fusion. Thus, at least in the setting of transplantation, BM serves as a reservoir for adipocyte progenitors, particularly in obese subjects.

Dates et versions

hal-01225085 , version 1 (05-11-2015)

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Mikael Rydén, Mehmet Uzunel, Joanna l. Hård, Erik Borgström, Jeff e. Mold, et al.. Transplanted Bone Marrow-Derived Cells Contribute to Human Adipogenesis. Cell Metabolism, 2015, 22 (3), pp.408-417. ⟨10.1016/j.cmet.2015.06.011⟩. ⟨hal-01225085⟩
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