The age and genomic integrity of neurons after cortical stroke in humans. - Institut Camille Jordan Accéder directement au contenu
Article Dans Une Revue Nature Neuroscience Année : 2014

The age and genomic integrity of neurons after cortical stroke in humans.

Résumé

It has been unclear whether ischemic stroke induces neurogenesis or neuronal DNA rearrangements in the human neocortex. Using immunohistochemistry; transcriptome, genome and ploidy analyses; and determination of nuclear bomb test-derived (14)C concentration in neuronal DNA, we found neither to be the case. A large proportion of cortical neurons displayed DNA fragmentation and DNA repair a short time after stroke, whereas neurons at chronic stages after stroke showed DNA integrity, demonstrating the relevance of an intact genome for survival.
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hal-01092159 , version 1 (08-12-2014)

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  • HAL Id : hal-01092159 , version 1
  • PUBMED : 24747576

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Hagen B Huttner, Olaf Bergmann, Mehran Salehpour, Attila Rácz, Jemal Tatarishvili, et al.. The age and genomic integrity of neurons after cortical stroke in humans.. Nature Neuroscience, 2014, pp.801-3. ⟨hal-01092159⟩
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